Acute effects of aldosterone on the epithelial 1 Na channel in rat kidney
نویسندگان
چکیده
Gustavo Frindt and Lawrence G. Palmer 5 6 7 Dept. of Physiology and Biophysics 8 Weill-Cornell Medical College 9 New York, NY 10065 10 11 12 13 14 15 16 17 18 19 20 Address for correspondence: 21 Lawrence G. Palmer, Ph.D. 22 Dept. of Physiology and Biophysics 23 Weill-Cornell Medical College 24 1300 York Avenue 25 New York, NY 10065 26 27 28 Running title: Acute effects of aldosterone 29 30 Articles in PresS. Am J Physiol Renal Physiol (December 17, 2014). doi:10.1152/ajprenal.00585.2014
منابع مشابه
Acute effects of aldosterone on the epithelial Na channel in rat kidney.
The acute effects of aldosterone administration on epithelial Na channels (ENaC) in rat kidney were examined using electrophysiology and immunodetection. Animals received a single injection of aldosterone (20 μg/kg body wt), which reduced Na excretion over the next 3 h. Channel activity was assessed in principal cells of cortical collecting ducts as amiloride-sensitive whole cell clamp current ...
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Activities of Na channels and Na pumps were studied in the rat cortical collecting tubule (CCT) during manipulation of the animals' mineralocorticoid status in vivo using a low-Na diet, diuretics, or administration of exogenous aldosterone. Tubules were isolated and split open to expose the luminal membrane surface. Using the whole-cell patch-clamp technique, activities of the apical Na channel...
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تاریخ انتشار 2014